Nattokinase is an all-natural, potent enzyme that is extracted from natto and highly purified. Natto is a fermented soybean food that has been consumed in Japan for over 1000 years. Nattokinase has been the subject of many studies, including human and animal trials. In 1980, researchers discovered that nattokinase demonstrated a positive effect on blood flow in vitro. Nattokinase may also support cardiovascular health.

How Nattokinase Works: Nattokinase supports healthy levels of fibrin and supports healthy blood flow through protease enzyme action (e.g., subtilisin protease, bacillopeptidase F).[2,3] Not only does nattokinase act directly on fibrin, but as demonstrated by in vitro work, its action also causes the release of substances that trigger the body’s production of other important enzymes that help regulate fibrin formation. Nattokinase can also inhibit a key enzyme that affects extracellular and arterial vasoconstriction, and it can generate tissue plasminogen activators.[4,5] Other in vitro work revealed that nattokinase caused a significant, dose-dependent decrease of red blood cell aggregation and low-shear viscosity, and these beneficial effects were evident at concentrations similar to those achieved with in vivo animal trials.[6] The Japanese have long believed that natto supports healthy blood flow. Now, as outlined above, modern science has uncovered mechanisms underlying this belief.

Dosage: Take one to two tablets twice daily at least 30 minutes before or two hours after a meal, or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

CAUTIONS: Consult your health care practitioner before taking this product if you have a bleeding disorder or are taking any drug that affects blood coagulation or blood pressure such as heparin, warfarin (Coumadin), diuretics, ACE inhibitors, or beta blockers.